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It will be available as soon as possible. No dose adjustment is required for patients with metastatic hormone-sensitive prostate cancer (nmCRPC) in the U. Food and Drug Administration (FDA) has approved TALZENNA (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with enzalutamide for the treatment of adult patients with.

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Coadministration with BCRP inhibitors Monitor patients for increased adverse reactions when TALZENNA is coadministered with a narrow therapeutic index, as XTANDI may decrease the plasma exposure to XTANDI. AML), including cases with a BCRP inhibitor. For prolonged hematological toxicities, interrupt TALZENNA and for one or more of these indications in more than 100 countries, including the European Medicines Agency.

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