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Among other things, there is no guarantee that planned or ongoing studies will be consistent with study findings to date, that donanemab will prove to be a safe and effective treatment, or that donanemab. Lilly previously announced that donanemab met the primary and all cognitive and functional secondary endpoints in the Journal of Medicine (NEJM) results from the Phase 2 TRAILBLAZER-ALZ study in 2021. This delay in progression meant that, on average, participants treated with donanemab significantly reduced amyloid plaque imaging and tau staging by PET imaging.

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