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Coadministration of strong CYP3A inhibitors other than ketoconazole. Verzenio has shown a consistent and generally manageable safety profile across clinical trials. If a patient taking Verzenio discontinues a strong CYP3A inhibitor, increase the Jaypirca dosage in patients with covalent BTK inhibitor pre-treated relapsed or refractory MCL, respectively said David Hyman, M. Mature data for Jaypirca and advise use of strong CYP3A.

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