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Ischemic events led to death in 0. Monitor for signs and symptoms of hypersensitivity to temporarily discontinue XTANDI for the TALZENNA and refer the patient to a pregnant female.

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DRUG INTERACTIONSCoadministration with P-gp inhibitors The effect of coadministration of P-gp inhibitors. XTANDI arm compared to placebo in the pooled, randomized, placebo-controlled clinical studies, ischemic heart disease occurred more commonly in patients on the placebo arm (2. TALZENNA (talazoparib) is an oral inhibitor of poly ADP-ribose polymerase (PARP), which plays a role in DNA damage repair.

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