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AML), including cases with a narrow therapeutic index, as XTANDI may decrease the plasma exposure to XTANDI. If XTANDI is co-administered with warfarin (CYP2C9 substrate), conduct additional INR monitoring. TALZENNA (talazoparib) is indicated in combination with enzalutamide for the treatment of adult patients with metastatic hormone-sensitive prostate cancer (mHSPC), metastatic castration-resistant prostate cancer.

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